Публикации: Эстетическая медицина
In vitro and in vivo study of dye diffusion into the human skin and hair follicles
Научно-образовательный Институт Оптики и Биофотоники. Саратовский государственный Университет, Саратов, Россия We present experimental results on the in vitro and in vivo study of dye diffusion into human skin and hair follicles. We have studied some commercially available dyes for potential using in the laser selective thermolysis. The degree and the depth of hair follicle dyeing inside the skin were determined. For hairs in different stages the sebaceous gland was stated as a reservoir for a dye administration. It was found that the penetration depth of dyes is about 1.2 mm from the skin surface. We have developed the biocompatible Indocyanine Green lotions and the method for in vivo dyeing and dye in depth monitoring. Shift on 16–21 nm of absorption peak of Indocyanine Green to the longer wavelengths due to Indocyanine Green binding with cell proteins in the human skin was found.
Optical Clearing of Skin Using Flashlamp-Induced Enhancement of Epidermal Permeability
Для журнала Lasers in Surgery and Medicine. Институт Оптики и Биофотоники. Саратовский государственный Университет, Саратов, Россия. Background and Objectives: Strong light scattering in skin prevents precise targeting of optical energy in therapeutic and diagnostic applic ations. Optical immersion based on matching refractive index of scattering centers with that of surrounding matter through introduction of an exogenous index-matching agent can alleviate the problem. However, slow diffusion of the index-matching agent through skin barrier makes practical implementation of this approach difficult. We propose a method of accelerating penetration of the index-matching compounds by enhancing skin permeability through creating a lattice of micro-zones (islets) of limited thermal damage in the stratum corneum (SC).
Научно-образовательный Институт Оптики и Биофотоники. Саратовский государственный Университет. Саратов, Россия. Optical clearing of human skin: comparative study of permeability and dehydration of intact and photothermally perforated skin
Skin Spectrophotometry under the Islet Photothermal Effect
Российский Институт оптики и биофотоники. Саратовский государственный университет. Россия. Research–Educational Institute of Optics and Biophotonics, Saratov State University, Saratov, 410026 Russia
A Pilot Study of ICG Laser Therapy of Acne Vulgaris: Photodynamic and Photothermolysis Treatment
Для журнала Lasers in Surgery and Medicine. Институт Оптики и Биофотоники. Саратовский государственный Университет, Саратов, Россия. The near-infrared (NIR) laser radiation due to its high penetration depth is widely used in phototherapy. In application to skin appendages, a high selectivity of laser treatment is needed to prevent light action on surrounding tissues. Indocyanine green (ICG) dye may provide a high selectivity of treatment due to effective ICG uploading by a target and its narrow band of considerable absorption just at the wavelength of the NIR diode laser. The goal of this study is to demonstrate the efficacy of the NIR diode laser phototherapy in combination with topical application of ICG suggested for soft and thermal treatment of acne vulgaris.